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Composition of Eleview®

Composition of Eleview®

A low-viscosity emulsion that’s easy to inject, Eleview® delivers long-lasting submucosal lift due to its unique composition.1,2 Learn more about how the components of Eleview® create long lift and provide increased margin visibility.1,2

See how Eleview® performs

Graphic of the components of Eleview® submucosal injection

Performance that adds greater efficiency

Eleview® composition: Dr. Luigi Moro

Dr. Luigi Moro discusses the components of Eleview®, their various functions, and the mechanism of action upon injection.

Eleview® ease of use

Hear how the low-viscosity composition of Eleview® solution contributes to ease of use during the injection process.

Methylene blue vs indigo carmine

Explore the differences between 2 staining agents, methylene blue and indigo carmine, as explained by Dr. Luigi Moro, CSO of Cosmo Pharmaceuticals.

Advantages of poloxamer 188

Dr. Luigi Moro discusses the advantages of poloxamer 188, a component of Eleview® submucosal injection agent.

Mechanism of action

View the mechanism of action for Eleview® submucosal injection agent.

Eleview® creates lift and visibility to help enhance procedures1,2

Functionality of the components of Eleview®

The components of Eleview® are key to creating reliable submucosal cushions and increasing the visibility of target lesion margins.1,2

Upon injection, Eleview® reconfigures and:

  • Forms a colored cushion1
  • Creates an "artificial net" of polymer chains1
  • Traps water within1
  • Builds a cushion of optimal shape, height, and duration1

Eleview® creates an artificial net of polymer chains

Upon injection, Eleview® creates an "artificial net" of polymer chains, trapping water within.1

Methylene blue enhances margin visibility

  • Provides detailed delineation of the lesion edges4
  • Stains the submucosal tissue4
  • Facilitates identification of muscle injury4
  • Enhances the post-resection view4

post -resection site with methylene blue staining

Post-resection site marked by methylene blue staining agent within Eleview®.

INDICATIONS FOR USE

Eleview® submucosal injectable composition is intended for use in gastrointestinal endoscopic procedures for submucosal lift of polyps, adenomas, early-stage cancers, or other gastrointestinal mucosal lesions, prior to excision with a snare or endoscopic device.

CONTRAINDICATIONS

Patients with known sensitivity to any of the components contained in Eleview®.

WARNINGS AND PRECAUTIONS

  • The endoscopist injecting Eleview® must be experienced in the administration technique.
  • The safety of Eleview® has not been established in pregnant or lactating women, or in children under 18 years of age.
  • Eleview® is provided in single-use ampoules. Eleview® should not be reused after the first opening. Any emulsion not injected during the procedure should not be reused for another endoscopic procedure.
  • Do not use if the primary packaging (ampoule) or secondary packaging (aluminum pouch) is damaged.
  • Do not use if the twist-off cap is damaged.
  • Do not use if the emulsion is not clear, shows any signs of opalescence, or contains floating or precipitated visible particles.
  • The product compatibility with other substances has not been tested.

ADVERSE REACTIONS

Rarely, local bleeding and/or inflammatory reaction could occur which may or may not be associated with Eleview®.

DOSAGE AND ADMINISTRATION

The administered dose of Eleview® should be determined based on the dimensions of the lesion to be removed. Inject into the submucosa the amount of Eleview® needed to form a submucosal cushion of optimal height and shape for the lesion to be removed. During the procedure do not exceed a total dose of 50 mL per patient, either in single or in multiple administrations.

Please see Instructions for Use for complete Important Safety Information.